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Clinical Solutions

Stroke, The Greatest Risk of Atrial Fibrillation (AF)

Atrial fibrillation, one of the most common arrhythmias in clinical practice, refers to the loss of regular, organized electrical activity in the atria, replaced by rapid, irregular fibrillation waves. It is typically characterized by an irregular and fast heart rate, caused by the atria losing their normal rhythm. Organic heart disease, autoimmune diseases, trauma, smoking, alcohol abuse, and family history are all factors that can lead to AF. Thromboembolism is the most significant complication of AF, with the highest incidence and greatest harm being stroke.

Studies have shown that 90% of thrombi in non-valvular AF patients originate from the left atrial appendage (LAA). A large data study on LAA thrombus before pulmonary vein isolation in 2019 once again confirmed that 100% of thrombus formation in AF patients originates from the LAA.

1.AF causes blood to stagnate in the LAA, gradually forming a thrombus

2.The unique anatomy of the LAA and its uneven internal musculature create eddies in the blood, promoting thrombus formation

3.Thrombi dislodge from the LAA and enter the arterial system

4.Thrombi become lodged in the cerebral vasculature, restricting blood flow and causing stroke

Stroke, The Greatest Risk of Atrial Fibrillation (AF)

Clinical Solutions

Stroke Prevention in Atrial Fibrillation

Oral Anticoagulant Medications

Oral anticoagulant medications primarily consist of warfarin and new oral anticoagulants (NOACs). Warfarin's effective dosage varies greatly among different individuals, the effective therapeutic window is narrow, and the coagulation function needs to be monitored regularly during the course of medication. Although NOACs can circumvent these issues, the disadvantages such as poor patient compliance and a high risk of bleeding are still unavoidable.
Left Atrial Appendage Excision/Ligation

Excising or ligating the LAA(the site of thrombus formation), through surgical or interventional methods can effectively eliminate the potential risk of thrombus formation. However, the procedures require opening the pericardium, which can lead to significant trauma and numerous postoperative complications. Additionally, LAA excision can impact on its physiological functions (such as hormone secretion); and LAA ligation often results in residual cavity issues. Moreover, the indications for the above procedures are narrow, only recommend by guidelines as incidental procedures during surgery.
Left Atrial Appendage Closure (LAAC)

By employing a minimally invasive interventional approach to place a closure device at the opening of the left atrial appendage , the LAAC procedure isolates the interior of the left atrium from the left atrial appendage,which effectively prevents the formation and dislodgment of thrombi in the left atrial appendage to reduce or prevent the occurrence of strokes. The LAAC procedure is known for its definitive efficacy, minimal trauma, no significant discomfort, quick recovery, safety, and high surgical success rate.

Clinical Solutions

Left Atrial Appendage Closure (LAAC)

Left Atrial Appendage Closure (LAAC) is a minimally invasive interventional treatment method that involves inserting a catheter through the femoral vein in the thigh to deliver a closure device to the left atrial appendage（LAAC). The closure device can unfold like an umbrella while reaching the LAAC to seal it off..In this way, even if thrombi form or become dislodged post-procedure, the closure device can isolate them within the LAAC , preventing them from dislodging or even traveling throughout the vasculature to avoid the risk of thromboembolic events. LAAC not only does not increase the bleeding risk for patients with atrial fibrillation., but also has its advantage in achieving anticoagulant effects while eliminating the patients' dependence on long-term oral anticoagulation therapy compared to anticoagulation medications, which offers a new treatment option for patients who cannot or do not wish to undergo long-term anticoagulation therapy and those at high risk of bleeding.

First Step

Advancing the left atrial appendage (LAA) access system into the left atrial appendage.
Second Step

Measuring the left atrial appendage using the device and select the appropriate size of the closure device before advancing it into the left atrial appendage.
Third Step

The physician uses the device to open and secure the left atrial appendage closure device in place,and then retrieves the catheter. Once the procedure is completed, the closure device separates the left atrial appendage from the left atrium.

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